Lorena Novoa-Aponte

Department of Chemistry and Biochemistry
Worcester Polytechnic Institute
60 Prescott St.
Room 4012, Gateway Park
Worcester, MA 01605
phone: 508-831-5731

I am a chemist particularly interested in understanding bacterial infection strategies. During my PhD studies at the Chemistry Department - Universidad Nacional de Colombia, I characterized membrane ion transporters of the intracellular pathogen Mycobacterium tuberculosis.
After spending six-months as a visiting graduate student, I joined Argüello's Lab as a post-doctoral fellow to apply cutting edge biochemical/system analyses to understand how metal homeostasis is established. In particular, I am using metallo-proteomics and bioinorganic methods to define molecular elements contributing to cytoplasmic copper distribution in Pseudomonas aeruginosa.
León-Torres A, Novoa-Aponte L & Soto, C. (2015) CtpA, a putative Mycobacterium tuberculosis P-type ATPase, is stimulated by copper (I) in the mycobacterial plasma membrane. BioMetals. 28(4):713-24.

Ayala-Torres, C., Novoa-Aponte, L. & Soto, C. (2015) Pma1 is an alkali/alkaline earth metal cation ATPase that preferentially transports Na+ and K+ across the Mycobacterium smegmatis plasma membrane. Microbiological Research.176:1–6.

Novoa-Aponte, L. & Soto C. (2014) Mycobacterium tuberculosis P-type ATPases: Possible targets for drug or vaccine development. BioMed Research International. Special issue - Research on Bacterial Virulence in the Developing Countries. 2014:1-9.

Pulido, P. A., Novoa-Aponte, L., Villamil, N., Soto, C. (2014) The DosR Dormancy Regulator of Mycobacterium tuberculosis Stimulates the Na+/K+ and Ca2+ ATPase Activities in Plasma Membrane Vesicles of Mycobacteria. Current Microbiology. 69:604-10.

Ayala-Torres C, Hernandez N, Galeano A, Novoa-Aponte L, Soto C. (2014) Zeta potential as a measure of the surface charge of mycobacterial cells. Annals of Microbiology. 64(3):1189–95.

Novoa-Aponte, L., León-Torres, A., Patiño-Ruiz, M., Cuesta-Bernal, J., Salazar, L.M., Landsman, D. Marino-Ramirez, L. & Soto, C. (2012) In silico Identification and characterization of the ion transport specificity for P-type ATPases in the Mycobacterium tuberculosis complex. BMC Structural Biology. 12(25):1-12.